5-AMINOVALERIC ACID

  • Name: 5-AMINOVALERIC ACID
  • CAS: 660-88-8
  • Purity: 99%
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Details

China cas 660-88-8 manufacturer wholesale 5-AMINOVALERIC ACID at affordable price

  • Molecular Formula: C5H11NO2
  • Molecular Weight: 117.148
  • Appearance/Colour: white to off-white crystalline powder 
  • Melting Point: 158-161 °C(lit.) 
  • Refractive Index: 1.4650 (estimate) 
  • Boiling Point: 247.5 °C at 760 mmHg 
  • PKA: 4.27(at 25℃) 
  • Flash Point: 103.5 °C 
  • PSA: 63.32000 
  • Density: 1.071 g/cm3 
  • LogP: 0.90030 

5-AMINOVALERIC ACID(Cas 660-88-8) Usage

Purification Methods

Crystallise it from H2O/EtOH. When heated above its melting point, it is converted to 2-piperidone with m 200o. [Wood & Colver J Am Chem Soc 67 654 1945, Beilstein 4 IV 2636.]

General Description

5-Aminovaleric acid (δAva) was utilized in the synthesis of Gramicidin S analogs, where it replaced L-leucyl-p-phenylalanyl residues to form [3-4-δAva]-GS and [3-4,3'-4'-bis(δAva)]-GS. The study demonstrated that incorporating 5-aminovaleric acid into the GS structure influenced the antimicrobial activity of the resulting analogs, highlighting the importance of amide bonds and side chains in the peptide's biological function. This suggests that 5-aminovaleric acid can serve as a flexible linker or modifier in peptide design, potentially altering the physicochemical and bioactive properties of the parent molecule.

Definition

ChEBI: A delta-amino acid comprising pentanoic acid with an amino substituent at C-5; a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist.

InChI:InChI=1/C5H11NO2/c6-4-2-1-3-5(7)8/h1-4,6H2,(H,7,8)

660-88-8 Relevant articles

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Fabrichnyi,B.P. et al.

, (1967)

-

Cationic–anionic palladium complexes: effect of hydrogen bond character on their stability and biological activity

Efimenko,Churakov,Ivanova,Erofeeva,Demina

, p. 1469 - 1478 (2017)

The solution state of palladium cationic...

An efficient enzymatic synthesis of 5-aminovaleric acid

Pukin, Aliaksei V.,Boeriu, Carmen G.,Scott, Elinor L.,Sanders, Johan P.M.,Franssen, Maurice C.R.

, p. 58 - 62 (2010)

The title compound was prepared enzymati...

An Integrated Cofactor/Co-Product Recycling Cascade for the Biosynthesis of Nylon Monomers from Cycloalkylamines

Sarak, Sharad,Sung, Sihyong,Jeon, Hyunwoo,Patil, Mahesh D.,Khobragade, Taresh P.,Pagar, Amol D.,Dawson, Philip E.,Yun, Hyungdon

, p. 3481 - 3486 (2020/12/17)

We report a highly atom-efficient integr...

Synthetic studies towards N-substituted 3-vinyl-4-piperidineacetic acid derivatives

Johnson, David A.,Gribble, Gordon W.

, p. 178 - 195 (2019/05/15)

The synthesis and full characterization ...

General Synthesis of Amino Acid Salts from Amino Alcohols and Basic Water Liberating H2

Hu, Peng,Ben-David, Yehoshoa,Milstein, David

supporting information, p. 6143 - 6146 (2016/06/09)

An atom-economical and environmentally f...

660-88-8 Process route

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4-Amino-2-methylbutyric acid

5-aminopentanoic acid
660-88-8

5-aminopentanoic acid

Conditions
Conditions Yield
With hydrogen; oxygen; In water; for 3h;
38%
4%
hydrogenchloride
7647-01-0,15364-23-5

hydrogenchloride

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chloroethane
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chloroethane

carbonic-acid
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carbonic-acid

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

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5-aminopentanoic acid
660-88-8

5-aminopentanoic acid

Conditions
Conditions Yield
at 180 - 190 ℃;

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    δ-aminovaleric acid ethyl ester

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